US researchers at Northwestern University have developed a technology called “microfluidic affinity for targeting infiltrating cells (MATIC)” that allows them to harvest up to 400% more tumor-osteoporotic cells to fight cancer better than previous methods. In some cases, it was even possible to make the tumors disappear completely. Scientists have now submitted their research work.
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seeking from Northwestern University They have developed a 3D-printable device that allows them to spread, sort, and harvest hundreds of millions of cells. 400% more osteoclasts are obtained than current methods. A new study shows that tumors can be significantly reduced in mice compared to traditional cell therapy methods. Thus the immune system can better defend itself against cancer.
Previous approach to cancer treatment
Cancer treatments often include toxic chemicals and foreign substances that cause harmful side effects and impair the body’s immune response. Using your own tissue can eliminate side effects and the risk of rejection.
Shana Kelly, author of the interview paper, said:
People have been cured of advanced skin cancer in the clinic by treatment with their own immune cells taken from tumor tissue. The problem is that it only works in very few patients because of the way the cells are harvested.”
Tumor infiltrating lymphocytes (TILs) are normal immune cells that invade tumor tissues and engage the cells in a type of hand-to-hand combat. The cellular therapies in use today are a mixture of “exhausted” and “naive” cells to treat tumors. Once the cells are extracted from the tissue, they are cultured in laboratories far from the patients from which they were taken. By the time the cells have multiplied and are ready for use in the patient’s body, many of the cells are exhausted and unable to fight because they have been in the tumor for so long.
“Targeting Microfluidic Affinity for Infiltration Cells (MATIC)”
This technique, called “targeting microfluidic affinity for infiltrating cells (MATIC)”, should help researchers localize the most active cells. In their work, the researchers used MATIC to find “Goldilocks pools” of cells from the mice they were looking for. It turned out that tumors in animals were significantly reduced or even completely disappeared. This would indicate a significant improvement in survival rates compared to previous methods.
Dr Kelly said:
“Instead of giving mice this mix of cells with different phenotypes, we give them the single cell phenotype that can actually help them. You see more efficacy and a much higher response rate when you really focus on the sweet spot of the T-cell interaction.”
The results are published in the journal with the article “Effective recovery of strong tumor-infiltrating lymphocytes through quantitative immunomagnetic cell sortingPublished the journal Nature Biomedical Engineering.
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