L ‘ARN It is a nucleic acid that is present in practically all living organisms, but also in some viruses. Its role is to transmit the necessary information that allows the synthesis of proteins necessary for the proper functioning of our cells.
What is mRNA?
mRNA is a temporary copy of the genes used as Models for making proteins. mRNA is not incorporated into the genome and only lasts for a few days. However, the researchers found that by adding mRNA to T cells, they could form transient CAR-T cells that only live for a few days. Then they damaged the hearts of the mice in a way that caused a lot of scarring and fibrosis. But two weeks after the mRNA nanoparticles were infused, the amount of scar tissue in the hearts of mice It was reduced by half.
The role of T cells
to This experimentThey used mice because they bear some similarities to human cells. The researchers wanted to repair damaged hearts while removing scar tissue. The treatment worked because the scar disappeared thanks to genetically modified immune cells, or CAR-T. These cells are already functional and are used in cancer treatment. The principle is to modify the cells to get more than amazing effects. In fact, T cells are immune cells to it the ability to detect virus-infected cells, which they then destroyed. T cells can be programmed to target any type of cell with the appropriate receptor.
What will CAR-T cells give?
It is made from the T cell, and it is designed to treat cancers especially leukemia or leukemia. The treatment has already begun and approved, but it is very expensive and It can cost up to $475,000. The transformation of a T cell to a CAR-T cell occurs inside the body. The generated mRNA will have a property similar to that found in coronavirus vaccines. On the other hand, other teams have tried to recreate a CAR-T cell by adding viruses to it, but this seems risky since the transformation takes place inside the body. Scientists hope that the CAR-T cell can also be used to treat damaged organs.
“Certified tv guru. Reader. Professional writer. Avid introvert. Extreme pop culture buff.”
More Stories
The Tech Campus divides the Neuberg Greens-Munich area
New chief data protection officer calls for more courage in digitalization
KickRender enables faster 3D rendering thanks to AI technology